Ionic liquids represent a highly tunable class of compounds whose physicochemical and biological properties can be modified through rational selection of cations and anions. In this study, three imidazolium-based ionic liquids containing oxychlorine anions were synthesized and characterized: 1-butyl-3-methylimidazolium chlorite, chlorate and perchl...

By Sara Klimenta, Andrija Vukov, Teona Teodora Borović, Jovana Selak, Snežana Papović, Milan Vraneš

Nicotine is a naturally occurring bicyclic alkaloid, composed of a pyridine ring connected to a pyrrolidine ring. Possessing two heterocyclic nitrogen atoms, it behaves like a dibasic compound in water. The pyrrolidine nitrogen has a pKa of approximately 8.0 while the pyridine nitrogen has a pKa of 3.12-3.41. Therefore, at physiological pH of 7.4 a...

By Andrija Vukov, Bojan Šarac, Domen Goste, Teona Teodora Borović, Jovana Selak, Snežana Papović, Milan Vraneš

Metformin is a first-line therapeutic agent for the management of Type 2 diabetes mellitus, owing to its well-balanced efficacy, safety profile, and affordability. As with all pharmacologically active compounds, understanding its behavior in aqueous environments is essential, particularly in the presence of additional components that may influence ...

By Jelena Macanović, Andrija Vukov, Teona Teodora Borović, Jovana Selak, Snežana Papović, Milan Vraneš