29.05.2026.
Abstract
Natural Sciences
EFFECT OF IONIZATION ON NICOTINE'S HYDRATION BEHAVIOUR
Nicotine is a naturally occurring bicyclic alkaloid, composed of a pyridine ring connected to a pyrrolidine ring. Possessing two heterocyclic nitrogen atoms, it behaves like a dibasic compound in water. The pyrrolidine nitrogen has a pKa of approximately 8.0 while the pyridine nitrogen has a pKa of 3.12-3.41. Therefore, at physiological pH of 7.4 a...
By Andrija Vukov, Bojan Šarac, Domen Goste, Teona Teodora Borović, Jovana Selak, Snežana Papović, Milan Vraneš