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ChemistryDepartment, EngineeringFaculty, Istanbul University-Cerrahpaşa , Istanbul , Turkey
Recently, there has been a significant progress regarding the biotechnological applications within the field of tissue engineering. One of such applications concerns the preparation of patterned polymeric scaffolds for patterned cell growth. Cell growth systems that make use of surface micro structuring and patterning have been gaining important traction as a result of their capacity to finely control cell growth and promote substrate adhesion. Being one of the numerous micro structuring techniques, soft lithography is a simple and sound technique for the preparation of nano-patterned polymeric scaffolds and was used in several studies to create patterned biopolymers on lamellas. In these studies, various lamellas were covered with different biopolymers and patterned using PDMS stamps which were prepared by passing UV light through a printed photomask that contained the desired pattern. The stamp replicates the opposite of the master. The same polymer master can be used many times without degradation. In Cell viability was observed on the prepared materials in this work. Viability of cell growth on these biopolymers was then studied with L929 mouse fibroblasts using Neutral Red Uptake Assay. The results showed a significant increase in cell growth on the patterned surfaces of the biopolymers.
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